- 2017.5.26A new article was published in CSF.
“SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation”
This paper shows that SEL1L-dependent substrates require Derlin2/3 and Herp1/2, regardless of their soluble or transmembrane Nature, in endoplasmic reticulum-associated degradation.
- 2017.4.12A new article was published in CSF.
“Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture”
This paper shows that synthesized Aβ42 caused lysosomal oxidative damage and rupture leading to cell death.
- 2017.4.4A new article was published in CSF.
“The WD40 Domain of HIRA Is Essential for RI-nucleosome Assembly in Xenopus Egg Extracts”
This paper shows that the WD40 domain of HIRA is essential for DNA replication-independent nucleosome assembly.
- 2017.3.18A new article was published in CSF.
“4μ8C inhibits insulin secretion independent of IRE1α RNase activity”
This paper shows that 4μ8C, an established inhibitor of IRE1α, has side-effects on insulin exocytosis.
- 2017.3.7A new article was published in CSF.
“PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides”
This paper summarizes recent findings of the intracellular roles of phosphoinositides PI5P and PI(3,5)P2.
- 2017.2.7A new article was published in CSF.
“TFE3, HSP47, and CREB3 pathways of the mammalian Golgi stress response”
This review article summarized recent findings of the mammalian Golgi stress response.
- 2016.12.8A new article was published in CSF.
“Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells”
This paper reports on the development of an improved FRET biosensor for in vitro diagnostic to predict the efficacy of molecular targeted therapy against CML.
- 2016.11.23A new article was published in CSF.
“A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology”
This paper reports on the development of a FRET biosensor for Rho-associated protein kinase (ROCK), of which substrate peptide sequence has been determined by KISS technology.
- 2016.10.12A new article was published in CSF.
“Pericentric H3K9me3 formation by HP1 interaction-defective histone methyltransferase Suv39h1”
This paper shows the possibility that Suv39h1-mediated heterochromatin formation can be controlled by multiple modules, including HP1.
- 2016.9.29A new article was published in CSF.
“Significance of extracellular vesicles: pathobiological roles in disease”
This paper overviews resent knowledge regarding extracellular vesicles, such as microparticles/microvesicles, exosomes and apoptotic bodies, produced from various cells that are activated by environmental stimuli.
- 2016.9.8A new article was published in CSF.
“Organization of non-centrosomal microtubules in epithelial cells”
This article overviews recent progresses in the research on the mechanisms of non-centrosomal microtubule assembly in epithelial cells.
- 2016.7.2A new article was published in CSF.
“Fertilization-independent cell-fusion between the synergid and central cell in the polycomb mutant”
This paper shows fertilization-independent autonomous synergid-endosperm fusion in msi1, an Arabidopsis mutant of Polycomb Repressive Complex 2.
- 2016.6.2A new article was published in CSF.
“MLX is a transcriptional repressor of the mammalian Golgi stress response”
This paper shows that a transcription factor MLX negatively regulates the TFE3 pathway of the mammalian Golgi stress response.
- 2016.5.28A new article was published in CSF.
“Multiplexed fluorescence imaging of ERK and Akt activities and cell-cycle progression”
This paper shows the involvement of cell cycle-dependent regulation of ERK and Akt activities by using multiplexed fluorescence reporters.
- 2016.5.27A new article was published in CSF.
“Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases”
This is the first review article describing multiple types of GEFs for Rab small GTPases.
- 2016.2.4A new article was published in CSF.
“Spätzle-processing enzyme-independent activation of the Toll pathway in Drosophila innate immunity”
This paper shows the existence of a novel factor activating the Toll pathway in Drosophila.
- 2016.1.9A new article was published in CSF.
“Atg101: not just an accessory subunit in the autophagy-initiation complex”
This paper reviews the structure and function of the autophagy factor
ATG101 that is not conserved in budding yeasts.
“Shape and area of keratocytes are related to the distribution and magnitude of their traction forces”
This paper shows that the shape of crawling cells, fish epidermal keratocytes, depends on the distribution of the traction forces, and that the magnitude of the traction forces depends on the area of the cells.
- 2015.12.22A new article was published in CSF.
“Mechanism of the dendritic translation and localization of brain-derived neurotrophic factor”
This paper shows that the specific 3’ UTR directs local translation of BDNF, which co-localizes with Bicaudal-D2 in neuronal dendrites.
- 2015.12.9A new article was published in CSF.
“Yeast Ivy1p is a putative I-BAR-domain protein with pH-sensitive filament forming ability in vitro”
This paper shows the pH-dependent polymerization of the yeast I-BAR domain protein Ivy1p.
- 2015.9.2We uploaded several experimental protocols from our society members. Please go to ‘Experimental protocol’ under ‘Experimental information’ on the left.
- 2015.7.22A new article was published in CSF.
“Phosphoproteomic analysis using the WW and FHA domains as biological filters”
This paper shows the novel focused phosphoproteomic approach to efficiently analyze intracellular phosphorylation signal networks.
- 2014.11.6Prof. Kazutoshi Mori was awarded the Albert Lasker Basic Medical Research Award 2014.
Prof. Kazutoshi Mori (Kyoto University), a long-contributing member of the Japan Society for Cell Biology, as well as an associate editor for Cell Structure and Function, was awarded the Albert Lasker Basic Medical Research Award 2014. The honor of this prize is shared with Prof. Peter Walter (UCSF) for their pioneering research revealing the molecular mechanism of the unfolded protein response (UPR), also known as the ER stress response. We congratulate Prof. Mori on being awarded the prize and express our high hopes for the further development of his research.
If you are interested in Prof. Mori’s research, please refer to his recent publications in Cell Structure and Function as follows.
The Antipsychotic Olanzapine Induces Apoptosis in Insulin-secreting Pancreatic β Cells by Blocking PERK-mediated Translational Attenuation
Riwa Ozasa, Tetsuya Okada, Satomi Nadanaka, Takahiko Nagamine, Alisha Zyryanova, Heather Harding, David Ron, Kazutoshi Mori
Cell Structure and Function 38: 183-195
Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish
Tokiro Ishikawa, Yoshihito Taniguchi, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
Cell Structure and Function 36: 247-259
SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line
Satoshi Ninagawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
Cell Structure and Function 36: 187-195
Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus
Yoshimi Sato, Satomi Nadanaka, Tetsuya Okada, Katsuya Okawa, Kazutoshi Mori
Cell Structure and Function 36: 35-47
pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation
Hiderou Yoshida, Aya Uemura, Kazutoshi Mori
Cell Structure and Function 34: 1-10
(CSF Award 2009 winning paper)
ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum
Yusuke Adachi, Keisuke Yamamoto, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori
Cell Structure and Function 33: 75-89
Reduction of Disulfide Bridges in the Lumenal Domain of ATF6 in Response to Glucose Starvation
Satomi Nadanaka, Hiderou Yoshida, Kazutoshi Mori
Cell Structure and Function 31: 127-134
XBP1 is Critical to Protect Cells from Endoplasmic Reticulum Stress: Evidence from Site-2 Protease-deficient Chinese Hamster Ovary Cells
Hiderou Yoshida, Satomi Nadanaka, Ryuichiro Sato, Kazutoshi Mori
Cell Structure and Function 31: 117-125
Analysis of ATF6 Activation in Site-2 Protease-deficient Chinese Hamster Ovary Cells
Satomi Nadanaka, Hiderou Yoshida, Ryuichiro Sato, Kazutoshi Mori
Cell Structure and Function 31: 109-116