- 2019.9.5A new article was published in CSF.
“Mutations in mxc Tumor-Suppressor Gene Induce Chromosome Instability in Drosophila Male Meiosis”
This paper describes the mechanism how a chromosome instability is given rise to during male meiosis in mutants of Drosophila tumor suppressor gene, mxc.
- 2019.8.31A new article was published in CSF.
“Identification of 15 new bypassable essential genes of fission yeast”
This paper presents the development of a bypass-of-essentiality screening in fission yeast.
- 2019.7.12A new article was published in CSF.
This is a review article on organelle zones.
- 2019.3.21A new article was published in CSF.
“A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection”
This paper identifies a peptide critical for endocytosis and influenza virus infection, and shows its potential for clinical application.
- 2019.3.21A new article was published in CSF.
“Two decades of genetically encoded biosensors based on Förster resonance energy transfer”
This paper overviews two decades of genetically encoded biosensors based on the principle of Förster resonance energy transfer.
- 2018.11.28A new article was published in CSF.
“PGSE is a novel enhancer regulating the proteoglycan pathway of the mammalian Golgi stress response”
This paper revealed the proteoglycan pathway, the novel response pathway of the mammalian Golgi stress response, and identified the enhancer element called PGSE.
- 2018.11.8A new article was published in CSF.
“Glycosphingolipid GM2 Induces Invasiveness in Irradiation-tolerant Lung Cancer Cells”
This paper shows that glycosphingolipid GM2 contributes to invasion in irradiation-tolerant lung cancer cells.
- 2018.7.26A new article was published in CSF.
“An anti-tumorigenic role of the Warburg effect at emergence of transformed cells”
This review article summarizes the novel role of the warburg-effect like metabolic changes to eliminate transformed cells from epithelia.
- 2018.7.26A new article was published in CSF.
“Automatic quantitative segmentation of myotubes reveals single-cell dynamics of S6 kinase activation”
This paper describes novel an automatic quantitative segmentation method of myotubes using fluorescent time-lapse images and demonstrates the different properties of S6K dynamics between myotube population and individuals.
- 2018.7.20A new article was published in CSF.
“Branched sialylated N-glycans are accumulated in brain synaptosomes and interact with Siglec-H”
This paper shows that branched sialylated N-glycans in synaptosomes play a role in the interaction of dendritic spines with microglia.
- 2018.7.13A new article was published in CSF.
“Mesoporous Silica Nanoparticles Rescue H2O2-induced Inhibition of Cardiac Differentiation”
This paper shows mesoporous silica nanoparticles exhibit protection against oxidative stress with respect to cardiac differentiation in human embryonic stem cells.
- 2018.6.29A new article was published in CSF.
“A novel morphological marker for the analysis of molecular activities at the single-cell level”
This paper shows a novel morphological marker for in vivo imaging and a method for analyzing the molecular activity in each cell by using machine learning.
- 2018.6.14A new article was published in CSF.
“Detailed analysis of the interaction of yeast COG complex”
This paper shows detailed analysis of the subunit interactions of the COG, tethering complex of the Golgi, in yeast.
- 2018.5.19A new article was published in CSF.
“Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel”
This paper shows that human iPS cells derived telencephalic neuron aggregates can be cultured for a long time on collagen gel.
- 2018.4.28A new article was published in CSF.
“Solo and keratin filaments regulate epithelial tubule morphology”
This paper shows that Solo, a RhoA-targeting GEF, and keratin filaments are involved in the elongated morphology of epithelial tubules.
- 2018.4.11A new article was published in CSF.
“Hidden Peptides Encoded by Putative Noncoding RNAs”
This paper summarize the peptides that have been recently identified as translation products of putative ncRNAs.
- 2018.3.17A new article was published in CSF.
“Live-cell imaging with genetically encoded protein kinase activity reporters”
This paper reviews the principles and applications of fluorescence reporters to visualize the kinase activities in living cells.
- 2018.2.23A new article was published in CSF.
“Structural Insights into the Altering Function of CRMP2 by Phosphorylation”
This paper describes the alteration of CRMP2 function for the microtubule dynamics by using the biochemical and structural analyses.
- 2018.2.15A new article was published in CSF.
“SPIRAL2 stabilises endoplasmic microtubule minus ends in the moss Physcomitrella patens”
This paper shows that moss SPIRAL2 (SPR2) protein is specifically localised to and stabilises the minus end of endoplasmic microtubules in protonemal cells.
- 2018.2.2A new article was published in CSF.
“A missense mutation in the NSF gene causes abnormal Golgi morphology in Arabidopsis thaliana”
This paper describes isolation of an Arabidopsis mutant showing abnormal Golgi morphology and demonstrates that it is due to a missense mutation in the membrane fusion factor NSF.
- 2018.1.18A new article was published in CSF.
“Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis”
This paper shows the pathological role of intestinal epithelial cell-intrinsic α-mannosidase II in an animal model of inflammatory bowel disease.
- 2017.12.28A new article was published in CSF.
“Flagellar-associated protein FAP85 is a microtubule inner protein that stabilizes microtubules”
This paper shows that /Chlamydomonas /flagellar-associated protein FAP85 is one of the microtubule inner proteins (MIPs).
- 2017.10.25A new article was published in CSF.
“Expression of Ror2 associated with fibrosis of the submandibular gland”
This paper shows expression pattern of molecules, including Ror2 receptor tyrosine kinase, in an inflammatory model of the submandibular gland.
“Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin”
This paper shows that bone marrow endothelial cells, a component of hematopoietic microenvironments, promote B cell egress in response to erythropoietin during the early phase of anemia, thereby regulating emergency hematopoiesis.
- 2017.9.23A new article was published in CSF.
“Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways”
This paper shows that deltamethrin, a type 2 pyrethroid, enhances neurite outgrowth of cortical neurons via endogenous BDNF.
- 2017.8.31A new article was published in CSF.
“The Position of the GFP Tag on Actin Affects the Filament Formation in Mammalian Cells”
This paper shows that the fusion position of the GFP tag on actin affects the filament formation of actin.
- 2017.7.13A new article was published in CSF.
“Drosophila DOCK family protein Zizimin involves in pigment cell differentiation in pupal retinae”
This paper shows that Drosophila DOCK family protein Zizimin involves in piment cell differentiation in pupal retinae.
- 2017.7.11A new article was published in CSF.
“Mitochondria regulate the differentiation of stem cells from human exfoliated deciduous teeth”
This paper shows that increased mitochondrial activity was crucial for the neuronal differentiation of stem cells from human exfoliated deciduous teeth.
- 2017.5.26A new article was published in CSF.
“SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation”
This paper shows that SEL1L-dependent substrates require Derlin2/3 and Herp1/2, regardless of their soluble or transmembrane Nature, in endoplasmic reticulum-associated degradation.
- 2017.4.12A new article was published in CSF.
“Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture”
This paper shows that synthesized Aβ42 caused lysosomal oxidative damage and rupture leading to cell death.
- 2017.4.4A new article was published in CSF.
“The WD40 Domain of HIRA Is Essential for RI-nucleosome Assembly in Xenopus Egg Extracts”
This paper shows that the WD40 domain of HIRA is essential for DNA replication-independent nucleosome assembly.
- 2017.3.18A new article was published in CSF.
“4μ8C inhibits insulin secretion independent of IRE1α RNase activity”
This paper shows that 4μ8C, an established inhibitor of IRE1α, has side-effects on insulin exocytosis.
- 2017.3.7A new article was published in CSF.
“PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides”
This paper summarizes recent findings of the intracellular roles of phosphoinositides PI5P and PI(3,5)P2.
- 2017.2.7A new article was published in CSF.
“TFE3, HSP47, and CREB3 pathways of the mammalian Golgi stress response”
This review article summarized recent findings of the mammalian Golgi stress response.
- 2016.12.8A new article was published in CSF.
“Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells”
This paper reports on the development of an improved FRET biosensor for in vitro diagnostic to predict the efficacy of molecular targeted therapy against CML.
- 2016.11.23A new article was published in CSF.
“A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology”
This paper reports on the development of a FRET biosensor for Rho-associated protein kinase (ROCK), of which substrate peptide sequence has been determined by KISS technology.
- 2016.10.12A new article was published in CSF.
“Pericentric H3K9me3 formation by HP1 interaction-defective histone methyltransferase Suv39h1”
This paper shows the possibility that Suv39h1-mediated heterochromatin formation can be controlled by multiple modules, including HP1.
- 2016.9.29A new article was published in CSF.
“Significance of extracellular vesicles: pathobiological roles in disease”
This paper overviews resent knowledge regarding extracellular vesicles, such as microparticles/microvesicles, exosomes and apoptotic bodies, produced from various cells that are activated by environmental stimuli.
- 2016.9.8A new article was published in CSF.
“Organization of non-centrosomal microtubules in epithelial cells”
This article overviews recent progresses in the research on the mechanisms of non-centrosomal microtubule assembly in epithelial cells.
- 2016.7.2A new article was published in CSF.
“Fertilization-independent cell-fusion between the synergid and central cell in the polycomb mutant”
This paper shows fertilization-independent autonomous synergid-endosperm fusion in msi1, an Arabidopsis mutant of Polycomb Repressive Complex 2.
- 2016.6.2A new article was published in CSF.
“MLX is a transcriptional repressor of the mammalian Golgi stress response”
This paper shows that a transcription factor MLX negatively regulates the TFE3 pathway of the mammalian Golgi stress response.
- 2016.5.28A new article was published in CSF.
“Multiplexed fluorescence imaging of ERK and Akt activities and cell-cycle progression”
This paper shows the involvement of cell cycle-dependent regulation of ERK and Akt activities by using multiplexed fluorescence reporters.
- 2016.5.27A new article was published in CSF.
“Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases”
This is the first review article describing multiple types of GEFs for Rab small GTPases.
- 2016.2.4A new article was published in CSF.
“Spätzle-processing enzyme-independent activation of the Toll pathway in Drosophila innate immunity”
This paper shows the existence of a novel factor activating the Toll pathway in Drosophila.
- 2016.1.9A new article was published in CSF.
“Atg101: not just an accessory subunit in the autophagy-initiation complex”
This paper reviews the structure and function of the autophagy factor
ATG101 that is not conserved in budding yeasts.
“Shape and area of keratocytes are related to the distribution and magnitude of their traction forces”
This paper shows that the shape of crawling cells, fish epidermal keratocytes, depends on the distribution of the traction forces, and that the magnitude of the traction forces depends on the area of the cells.
- 2015.12.22A new article was published in CSF.
“Mechanism of the dendritic translation and localization of brain-derived neurotrophic factor”
This paper shows that the specific 3’ UTR directs local translation of BDNF, which co-localizes with Bicaudal-D2 in neuronal dendrites.
- 2015.12.9A new article was published in CSF.
“Yeast Ivy1p is a putative I-BAR-domain protein with pH-sensitive filament forming ability in vitro”
This paper shows the pH-dependent polymerization of the yeast I-BAR domain protein Ivy1p.
- 2015.9.2We uploaded several experimental protocols from our society members. Please go to ‘Experimental protocol’ under ‘Experimental information’ on the left.
- 2015.7.22A new article was published in CSF.
“Phosphoproteomic analysis using the WW and FHA domains as biological filters”
This paper shows the novel focused phosphoproteomic approach to efficiently analyze intracellular phosphorylation signal networks.
- 2014.11.6Prof. Kazutoshi Mori was awarded the Albert Lasker Basic Medical Research Award 2014.
Prof. Kazutoshi Mori (Kyoto University), a long-contributing member of the Japan Society for Cell Biology, as well as an associate editor for Cell Structure and Function, was awarded the Albert Lasker Basic Medical Research Award 2014. The honor of this prize is shared with Prof. Peter Walter (UCSF) for their pioneering research revealing the molecular mechanism of the unfolded protein response (UPR), also known as the ER stress response. We congratulate Prof. Mori on being awarded the prize and express our high hopes for the further development of his research.
If you are interested in Prof. Mori’s research, please refer to his recent publications in Cell Structure and Function as follows.
The Antipsychotic Olanzapine Induces Apoptosis in Insulin-secreting Pancreatic β Cells by Blocking PERK-mediated Translational Attenuation
Riwa Ozasa, Tetsuya Okada, Satomi Nadanaka, Takahiko Nagamine, Alisha Zyryanova, Heather Harding, David Ron, Kazutoshi Mori
Cell Structure and Function 38: 183-195
Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish
Tokiro Ishikawa, Yoshihito Taniguchi, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
Cell Structure and Function 36: 247-259
SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line
Satoshi Ninagawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
Cell Structure and Function 36: 187-195
Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus
Yoshimi Sato, Satomi Nadanaka, Tetsuya Okada, Katsuya Okawa, Kazutoshi Mori
Cell Structure and Function 36: 35-47
pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation
Hiderou Yoshida, Aya Uemura, Kazutoshi Mori
Cell Structure and Function 34: 1-10
(CSF Award 2009 winning paper)
ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum
Yusuke Adachi, Keisuke Yamamoto, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori
Cell Structure and Function 33: 75-89
Reduction of Disulfide Bridges in the Lumenal Domain of ATF6 in Response to Glucose Starvation
Satomi Nadanaka, Hiderou Yoshida, Kazutoshi Mori
Cell Structure and Function 31: 127-134
XBP1 is Critical to Protect Cells from Endoplasmic Reticulum Stress: Evidence from Site-2 Protease-deficient Chinese Hamster Ovary Cells
Hiderou Yoshida, Satomi Nadanaka, Ryuichiro Sato, Kazutoshi Mori
Cell Structure and Function 31: 117-125
Analysis of ATF6 Activation in Site-2 Protease-deficient Chinese Hamster Ovary Cells
Satomi Nadanaka, Hiderou Yoshida, Ryuichiro Sato, Kazutoshi Mori
Cell Structure and Function 31: 109-116