2026.02.25

Functional analysis of miR-199a-3p in tumor endothelial cells

Tumor endothelial cells highly express miR-199a-3p, which promotes their proliferation, migration, and invasion while reducing their adhesion to the extracellular matrix by downregulating the tetraspanin CD151.

2026.02.10

Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix

Highly brain-metastatic melanoma cells on a soft extracellular matrix showed low-expression of a proliferation-inhibitor EGR1.

2026.02.10

A mei-P26 is required for initiation of meiosis in the Drosophila male germline

A member of the TRIM-NHL protein family, Mei-P26 is essential for initiating meiosis in the Drosophila male germline; its loss leads to failure of Cdk1 activation.

2026.02.03

Multiplex live imaging approaches to interrogate the interplay of multiple signaling pathways

This review article provides an overview of recent advances in multiplex live imaging technologies for dissecting the interplay of signaling dynamics in research fields such as cancer biology.

2026.01.28

Cholesterol in glioblastoma: impaired Hh signaling enhances epigenetic modifiers and decreases CAV1

This paper explains that high cholesterol and increased CAV1 expression promotes stem-like characteristics in glioma spheroids. Reduction of cholesterol hampers hedgehog signaling and provokes expression of epigenetics modifiers causing epigenetic silencing of CAV1 impacting loss of stem-like phenotypes.