Cell biological insights into human STING variants

This paper highlights the function of human STING variants and their associated diseases

BiP, GRP94, Calreticulin and Calnexin Contribute to Development of the Notochord in Medaka Fish

This paper shows that ER-localized molecular chaperones, BiP, GRP94, calreticulin, and calnexin, contribute development of the notochord in medaka fish.

A quantitative method to monitor STING degradation with dual-luciferase reporters

This paper shows a new high-throughput assay system to quantify the degradation of an innate immune protein STING.

Chemokine induces phase transition from non-directional to directional migration during angiogenesis

This paper reports on how sprouting endothelial cells migrate toward the target vessels during the formation of the cerebral capillary network.

Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages

In this paper, we show that macropinocytosis regulates the Erk pathway to modulate cytokine expression.

Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research

This paper comprehensively reviews the fluorescent sensors that visualize cell cycle regulatory CDK activities in real-time within living cells.

Tango1L but not Tango1S, Tali and cTAGE5 is required for export of type II collagen in medaka fish

This paper shows that only Tango1L is required for enlargement of COPII vesicles among 2 genes (2 splicing variants each) in medaka fish.

Live imaging of paracrine signaling: Advances in visualization and tracking techniques

This paper provides an overview of methods for visualizing paracrine signaling, which is a major mechanism of cell-to-cell communication.

The Role of Primary Cilia in Myoblast Proliferation and Cell Cycle Regulation during Myogenesis

This paper reviews the role of cilia in the myogenesis process, particularly in controlling the balance between myoblast proliferation and differentiation, and progress in imaging techniques for their analysis.

Impact of physiological ionic strength and crowding on kinesin-1 motility

This paper shows that ionic strength and molecular crowding close to intracellular levels maintain high kinesin motility.

Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles

This paper shows that internalized magnetic nanoparticles in cancer cells enable magnetic control of membrane damage in early endosomes.

A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription

This paper shows a sensitive ERK activity probe, EKAREN5-gl, which can detect low-dose EGF-induced activity.

Multi-color fluorescence live-cell imaging in Dictyostelium discoideum

This paper describes development of 5-color live fluorescence imaging in Dictyostelium discoideum.

Possible roles of CAHS proteins form Tardigrade in osmotic stress tolerance in mammalian cells

This paper shows that tardigrade CAHS proteins form reversible aggregates upon hyperosmotic stimulation and confer stress resistance in HeLa cells.

The expression of the formin Fhod3 in mouse tongue striated muscle (jst.go.jp)

This paper shows the expression and subcellular localization of Fhod3, an actin polymerization factor, in striated muscle of the mouse tongue.

Cell-wide arrangement of Golgi/RE units depends on the microtubule organization (jst.go.jp)

This paper shows Golgi stacks gathered to form a "Golgi ring" surrounding the centric REs beneath the cilium in sea urchin and ascidian embryonic cells.

Molecular Alterations Associated with Pathophysiology in Liver-Specific ZO-1 and ZO-2 Knockout Mice (jst.go.jp)

This paper provides a comprehensive temporal analysis of molecular changes in ZO-1 and ZO-2 deficient livers, offering insights into the pathology associated with ZO deficiency.

Visualization of ER-to-Golgi trafficking of procollagen X (jst.go.jp)

This paper visualized the ER-to-Golgi transport of procollagen X, which is involved in cartilage remodeling, and analyzed the proteins required for its transport.

Deep learning-based segmentation of subcellular organelles in high-resolution phase-contrast images (jst.go.jp)

This paper shows the development of deep learning-based segmentation models for organelles in high-resolution phase-contrast images.

Deciphering the sub-Golgi localization of glycosyltransferases via 3D super-resolution imaging (jst.go.jp)

This paper visualized the distribution of glycosyltransferases within the Golgi of mammalian cells and explored the determinants of their sub-Golgi localization.

Reconstitution of nuclear envelope subdomain formation on mitotic chromosomes in semi-intact cells

This paper shows development of in vitro nuclear envelope reconstitution system using semi-intact cells.

A high-resolution phase-contrast microscopy system for label-free imaging in living cells

This paper shows a tuned-up phase-contrast microscopy system for visualizing dynamic organelle behaviors.

In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila

Lysosomal membrane integrity in fibroblasts derived from patients with Gaucher disease

This paper shows that the lysosomal membranes of cells derived from patients with Gaucher disease are susceptible to damage.

Coronin-1 promotes directional cell rearrangement in Drosophila wing epithelium

This paper shows that Coronin-1, which is an actin regulator, promotes cell rearrangement.