The Bi lab is seeking a postdoc to conduct pioneering study on the mechanism of nuclear migration and abscission in a morphologically striking yeast whose genome has just been sequenced and annotated, for the first time, in our laboratory. Our eventual goal is to develop this yeast as a powerful system for studying any fundamental process. Our initial focus is to develop genetic tools and molecular probes for live imaging of the cytoskeleton and motor proteins during its life cycle. This is an incredibly exciting opportunity! Highly motivated individuals with a Ph.D. in biological sciences are welcome to apply. Stipends will be paid according to the NIH guideline (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-048.html).
To apply, please send your CV, a short summary of your current research, and two letters of recommendation to Dr. Erfei Bi (ebi@mail.med.upenn.edu; Tel: 215-573-6676), Professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-6058. You can also learn more about other research activities in our lab by reading some of our recent papers:
1. Oh, Y., and E. Bi. 2011. Septin structure and function in yeast and beyond. Trends Cell Biol. 21:141-148.
2. Oh, Y., K.J. Chang, P. Orlean, C. Wloka, R. Deshaies, and E. Bi. 2012. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Mol. Biol. Cell 23:2445-2456.
3. Bi, E.,* and H.-O. Park. 2012. Cell polarization and cytokinesis in budding yeast. Genetics 191:347-387（the article will also appear as a chapter in YeastBook) (*corresponding author).
4. Wloka, C., E.A. Vallen, L. Thé, X. Fang, and E. Bi. 2013. Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast. J. Cell Biol. 200:271-286. (Highlighted in Biosights with a podcast entitled “Erecting a scaffold for cytokinesis”).
5. Okada, S., M. Leda, J. Hanna, N.S. Savage, E. Bi*, and A. Goryachev*. 2013. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev. Cell: 26:148-161 (Cover story for the July 28th 2013 issue, with a commentary entitled "Bud building by septin patch hole punching") (*co-corresponding author).
6. Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. 2014. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. J. Cell Sci. 127:2483-92 (Highlighted in “In this issue” with a piece entitled “ Cytokinesis links polarization and tube formation in liver”).
7. Ong K, Wloka C, Okada S, Svitkina T*, Bi E*. 2014. Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle. Nature Communications. Dec 5;5:5698. doi: 10.1038/ncomms6698. (*co-corresponding author)
